期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 65, 期 -, 页码 1-7出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2014.01.003
关键词
Collagen; Hydroxyapatite; Silk fibroin
资金
- National Natural Science Foundation of China [31071265, 30900297]
- Research Fund for the Doctoral Program of Higher Education [20090141120055]
A new in situ precipitation technique was developed to synthesize collagen-silk fibroin/hydroxyapatite nanocomposites. The componential properties and morphological of nanocomposites were investigated. It was revealed that the inorganic phase in the nanocomposite was carbonate-substituted hydroxyapatite with low crystallinity. Morphology studies showed that hydroxyapatite particles with size ranging from 30 to 100 nm were distributed uniformly in the polymer matrix. According to the TEM micrographs, inorganic particles were composed of more fine sub-particles whose diameters were between 2 and 5 nm in size without regular crystallographic orientation. The mechanical properties of the composites were evaluated by measuring their elastic modulus. The data indicated that the elastic modulus of nanocomposites was improved by the addition of silk fibroin. Finally, the cell biocompatibility of the composites was tested in vitro, which showed that they have good biocompatibility. These results suggest that the collagen-silk fibroin/hydroxyapatite nanocomposites are promising biomaterials for bone tissue engineering. (C) 2014 Elsevier B.V. All rights reserved.
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