期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 63, 期 -, 页码 114-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2013.10.037
关键词
Schisandra chinensis (Turcz.) Baill; Polysaccharide; 5-Fluorouracil; Combination; Enhanced antitumor; Reduced toxicity
资金
- Natural Science Fund of Jiangu Province [BK2012702]
Previous study indicated that the refined polysaccharide from Schisandra could improve the CTX-induced inhibition of T and B lymphocytes proliferation. Accordingly, the enhanced antitumor and reduced toxicity effects of a low molecular weight purified polysaccharide from Schisandra (SCPP11) were investigated in 5-fluorouracil (5-Fu) treated Heps-bearing mice. The results revealed that the SCPP11 (oral administration) exhibited a significant enhanced effect of antitumor activity when combined with 5-Fu. Moreover, a increased effect was also observed in boosting immunity functions when the Heps-bearing mice receiving SCPP11 combination with 5-Fu administration, including increased in thymus indexes and enhancing serum IL-2 and TNF-alpha. secretion. In addition, SCPP11 could ameliorate the hematological and biochemical parameters changes induced by 5-Fu to normal level, and reduce the formation of MDA and enhance the activities of SOD in liver to against 5-Fu induced free radical damage. The above results suggested that the SCPP11 combined with 5-Fu presented enhanced effects on antitumor activity and the SCPP11 could attenuate the 5-Fu-induced toxicity effect. It could serve as a new and promising adjuvant for chemotherapy drugs. (C) 2013 Elsevier B.V. All rights reserved.
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