期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 57, 期 -, 页码 1-8出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2013.02.010
关键词
G-quadruplex; Promoter; Telomere; Terpyridine; Pt(II) complex
资金
- National Natural Science Foundation of China [21041008, 21171108]
- Specialized Research Fund for the Doctoral Program of Higher Education [20101401110009]
- Shanxi Scholarship Council of China [2011-016]
Three terpyridine derivatives L1-L3 and their Pt(II) complexes 1-3 have been prepared, the binding interactions with human telomeric (h-telo) and the promoter c-kit2 and c-myc G-quadruplex DNAs were investigated. All the ligands and the complexes are potent stabilisers of the G-quadruplex structures and exhibit the G-quadruplex selectivity over duplex. The binding affinities of these compounds to G-quadruplexes are higher than to calf thymus DNA. Three Pt(II) complexes are also potent telomerase inhibitors. CD spectra show that both the ligands and the complexes can induce the formation of anti-parallel G-quadruplex structure of h-telo in the absence and presence of K+. Each h-telo G-quadruplex binds two ligand or complex molecules using Job plot analysis. (C) 2013 Elsevier B.V. All rights reserved.
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