期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 50, 期 3, 页码 833-839出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2011.11.017
关键词
Carboxymethyl tamarind kernel powder; Tropicamide; Ionotropic gelation; Nanoparticles; Corneal permeation
资金
- Department of Science & Technology, Govt. of India
- Haryana State Government
Tropicamide-loaded carboxymethyl tamarind kernel polysaccharide (CMTKP) nanoparticles were prepared and evaluated for ocular delivery. Preparation of ionotropically gelled CMTKP nanoparticles was optimized employing three-levels, two-factor central composite design. Concentration of polymer and crosslinker had significant synergistic effect on particle size and % encapsulation efficiency. The optimal calculated parameters were concentrations of CMTKP 0.10% (w/v) and calcium chloride 0.11% (w/v). The optimized tropicamide-loaded CMTKP formulation showed ex vivo corneal permeation of tropicamide across isolated goat cornea comparable to its aqueous solution. Further, the mucoadhesive and non-irritant nature of CMTKP nanoparticles indicate their suitability as ocular delivery system. (C) 2011 Elsevier B.V. All rights reserved.
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