期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 51, 期 4, 页码 412-416出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2012.05.028
关键词
Dengue virus; Antiviral activity; Algal sulfated polysaccharides; Sugar composition
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
- Universidad de Buenos Aires, Argentina
- Department of Science and Technology [SR/S1/OC-50/2007]
Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20 mu g/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization. (C) 2012 Elsevier B.V. All rights reserved.
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