期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 51, 期 5, 页码 887-891出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2012.06.037
关键词
Glycogen; Transmission electron microscopy; Dynamic light scattering
资金
- National Health and Medical Research Council
- Melbourne Materials Institute in the University of Melbourne
Transmission electron micrographs of glycogen extracted from healthy mouse hearts reveal aggregate structures around 133 nm in diameter. These structures are similar to, but on average somewhat smaller than, the alpha-particles of glycogen found in mammalian liver. Like the larger liver glycogens, these new particles in cardiac tissue appear to be aggregates of beta-particles. Free beta-particles are also present in liver, and are the only type of particle seen in skeletal muscle. They have diameters from 20 to 50 nm. We discuss the number distributions of glycogen particle diameters and the implications for the structure-function relationship of glycogens in these tissues. We point out the possible implications for the study of glycogen storage diseases, and of non-insulin dependent diabetes mellitus. (C) 2012 Elsevier B.V. All rights reserved.
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