4.7 Article

Antitumor and immunomodulatory activity of polysaccharides from the root of Limonium sinense Kuntze

期刊

出版社

ELSEVIER
DOI: 10.1016/j.ijbiomac.2012.08.037

关键词

Limonium sinense (Girard) Kuntze; Polysaccharides; Antitumor activity; Immunomodulatory activity

资金

  1. Natural Science Fund of Jiangsu Province [BK2009172, BK2011422]
  2. Innovation and Entrepreneurship Training Program Projects for the Chinese College Students
  3. Practice Innovation Training Program Projects for the Jiangsu College Students

向作者/读者索取更多资源

Limonium sinense (Girard) Kuntze is a traditional Chinese folk medicine used for the treatment of fever, hemorrhage, hepatitis and other disorders. The study focused on the antitumor and immunomodulatory activities of L. sinense polysaccharides (LSP) which was obtained from the root of the plant. The antitumor effects of only LSP and LSP in combination with 5-fluorouracil (5-FU) were both evaluated with Heps-bearing tumor mice models. In addition, the macrophage phagocytosis assay, splenocyte proliferation and cytokines production tests were used to assess the immunomodulatory activities of LSP. The results revealed that the LSP (at the dose of 200 and 400 mg/kg) had an obvious inhibition on the growth of transplanted mouse tumor. It also exhibited a significant synergistic effect of antitumor activity when combined with 5-FU (p < 0.05). Furthermore, the LSP (at the dose of 100 and 200 mg/kg) remarkably improved macrophage phagocytosis function in immune suppressed mice. In addition, LSP (at the dose of 50-200 mu g/ml) showed significant synergistic effects on ConA-stimulated proliferation and IFN-gamma and IL-2 production of splenocyte in vitro (p < 0.05). These findings suggest that LSP had clear antitumor activity which might be related to its regulation of immune function in mice. (C) 2012 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据