期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 49, 期 4, 页码 573-579出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2011.06.011
关键词
Tissue engineering; Polyelectrolyte complexes; Polymeric scaffolds; Cytotoxicity
资金
- Portuguese Foundation for Science and Technology [PTDC/EME-TME/103375/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/EME-TME/103375/2008] Funding Source: FCT
In the present study, small-sized porous scaffolds were obtained from the freeze-drying of sodium hyaluronate/chitosan polyelectrolyte complexes. The obtained materials were characterized by a set of techniques including attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, swelling determination and weight loss studies. The morphology of the scaffolds was observed using scanning electron microscopy. Thermal characterization of the scaffolds was also performed by dynamic mechanical thermal analysis and thermogravimetric analysis. Finally, the cytotoxic profile of the prepared scaffolds was evaluated in vitro, using mesenchymal stem cells. The results obtained showed that cells adhered to scaffolds and proliferated. This study also confirmed that the degradation by-products of sodium hyaluronate/chitosan scaffold are noncytotoxic, which is fundamental for its application in the biomedical field. (C) 2011 Elsevier B.V. All rights reserved.
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