期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 49, 期 4, 页码 729-736出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2011.07.004
关键词
i-Motif; Human telomere; Multivariate analysis; Loops; TMPyP4 binding
资金
- Spanish government [CTQ2009-11572, CTQ2010-20541-C03-01]
- Catalan government [2009 SGR 45, 2009 SGR 238]
The influence of pH, temperature and the cationic porphyrin TMPyP4 on the conformational equilibria of the cytosine-rich strand of the human telomeric sequence 5'-(C(3)TA(2))(4)-3', as well as those of the sequence 5'-(C3TT2)(4)-3', was studied. The presence of adenine bases at the loops causes the formation of two different intramolecular i-motif structures with a pH-transition midpoint around 4.6, which stability is lower than the i-motif formed by the sequence 5'-(C3TT2)(4)-3'. The stoichiometries of the complexes formed by these i-motif structures with TMPyP4 are also influenced by the presence of adenine at the loops. (C) 2011 Elsevier B.V. All rights reserved.
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