期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 46, 期 1, 页码 126-130出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2009.10.008
关键词
Chitosan; Reversible addition fragmentation chain transfer (RAFT); Nanoparticles; pH- and thermo-sensitive; Acrylic acid
资金
- Natural Science Foundation of China [50903060]
- Natural Science Foundation of Jiangsu Province [BK2007547]
- Program of Innovative Research Team of Soochow University
- Key Project in Science & Technology Innovation Cultivation Program of Soochow University
- Key Laboratory of Organic Chemistry of Jiangsu Province
Thermo- and pH-sensitive chitosan-based nanoparticles were successfully prepared by one-pot polymerization of acrylic acid/chitosan with poly(N-isopropylacrylamide) (PNIPAM) macro-RAFT agent. The spherical and monodisperse nanoparticles were obtained with the diameters of about 100 nm at 25 degrees C (pH=6.5), and PNIPAM was anchored as the shell via the RAFT process. The disorder shell and the large aggregates were observed at 40 degrees C (pH=6.5); and the spherical nanoparticles broke up at 25 degrees C when pH was lowered to 3. This work may provide a facile one-pot method to prepare functionalized chitosan-based nanoparticles without N-phthaloylation of chitosan in the process. (C) 2009 Elsevier B.V. All rights reserved.
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