期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 45, 期 5, 页码 532-534出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2009.09.002
关键词
Denaturation transition; UV absorption spectroscopy; DNA in mixed solvents
资金
- National Science Foundation [DMR-0454672]
DNA undergoes a helix-to-coil transition (also called denaturation transition) upon heating This transition can also be facilitated by using solvent mixtures (for example water-alcohol) An increase in the hydrophobic tail of the second solvent molecule first decreases then increases the melting temperature appreciably. Measurement on 4% DNA in a series of water-alcohol mixtures shows that the helix-to-coil melting transition is driven by the solvent ability to cross the hydrophobic sugar-rich region DNA is behaving like a cylindrical micelle. Published by Elsevier B.V.
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