期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 45, 期 3, 页码 284-288出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2009.06.010
关键词
Rat; Liriope polysaccharides; Extraction; SS; Response surface methodology (RSM); Optimization
The response surface methodology (RSM) was employed to study the extraction of liriope polysaccharides. The maximum extraction rate (64.1%) of liriope polysaccharides obtained by using the above optimised concentrations of the variables was extraction time (X-1) at 185 min, ratio of liquid to solid (X-2) at 11, and extraction temperature (X-3) at 94 degrees C. Forty male Wistar rats were used in the present experiment. After 2 weeks of acclimatization, animals were divided into 5 equal groups: control, SS model and 3 polysaccharides-treatment groups. Rats were orally administered their respective doses every day for 6 weeks. Liriope polysaccharides significantly increased the amount of salivary secretion, and the relative weight of spleen, thymus and submandibular glands. Therefore, the present results revealed that liriope polysaccharides exert a protective effect against tissue damage in rats with sjogren syndrome (SS). (C) 2009 Elsevier B.V. All rights reserved.
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