期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 44, 期 5, 页码 435-440出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2009.03.004
关键词
Cation-independent mannose 6-phosphate receptor; Reptiles (calotes); IGF-II binding; M6P/IGF-II receptor; Evolution
资金
- DST [SR/SO/BB/60-2003]
- Volkswagen Stiftung, Germany [1/78913]
- CSIR, New Delhi, India
The mammalian cation-independent mannose 6-phosphate/insulin-like growth factor (IGF)-II receptor binds IGF-II with high affinity. Ligands transported by the MPR 300/IGF-IIR include IGF-II and mannose 6-phosphate-modified proteins. By targeting IGF-II to lysosomal degradation, it plays a key role in the maintenance of correct IGF-II levels in the circulation and in target tissues. Although, from our studies we found homologous receptor in calotes but its functional significance was not known. We present here the first report on the calotes MPR 300/IGF-IIR binds IGF-II with K-d of 12.02 nM; these findings provide new and strong evidence that MPR 300/IGF-IIR in Calotes versicolor binds IGFII with high affinity. (C) 2009 Elsevier B.V. All rights reserved.
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