期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 43, 期 2, 页码 142-150出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2008.04.008
关键词
drug delivery; hydrogels; sterculia gum
The present paper deals with the modification of the sterculia gum with methacrylic acid (MAAc) to hydrogels for use in drug delivery. The hydrogels were characterized by SEMs, FFIR and swelling studies. The release dynamics of model anti-ulcer drug (ranitidine hydrochloride) from the hydrogels has been studied for the evaluation of the release mechanism. The values of the diffusion exponent 'n'(0.55,0.54 and 0.59) and gel characteristic constant 'k' (2.109 x 10(-2), 3.698 x 10(-2) and 2.427 x 10(-2)) have been obtained, respectively, in distilled water, pH 2.2 buffer and pH 7.4 buffer. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism. (C) 2008 Elsevier B.V. All rights reserved.
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