期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 50, 期 -, 页码 55-59出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.01.019
关键词
Organelles; Endoplasmic reticulum; Mitochondria; Calcium signaling
资金
- Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile
- FONDECYT [1120212, 11130285, 3130749]
- Anillo [ACT1111]
- FONDAP [15130011]
- Red Internacional [120003]
- National Institutes of Health [HL-075173, HL-080144, HL-090842]
- American Heart Association [0640084N, 7-08-MN-21-ADA]
- AHA-Jon Holden DeHaan Foundation [0970518N]
- Natural Sciences and Engineering Research Council [386757-2010]
- CONICYT
- Pew Charitable Trust Postdoctoral Fellowship
Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies. (C) 2014 Elsevier Ltd. All rights reserved.
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