期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 55, 期 -, 页码 264-268出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.09.014
关键词
Electric field; PI3K/Akt; PTEN; EGFR; AChR and NMDAR; MAPK; Electrotaxis
资金
- European Research Council StG grant [243261]
- Royal Society URF award [UF051616]
- The British Council [GII112] Funding Source: researchfish
Physiological electric field (EF) is a potent guidance cue for many physiological development and pathological conditions. The EF induced cellular responses such as migration and proliferation, are considered to be regulated by multiple signaling pathways in a coordinated way. Unlike the signaling transduction regulating the cellular responses toward chemical gradients, the signaling network involved in electric stimulation shows a unique manner, combining the regulation of ion channels, membrane receptors and associated intracellular signaling pathways. This review shall discuss the cellular responses in EF, and summarize the primary signaling network activated during the EF-induced cellular response. (C) 2014 Elsevier Ltd. All rights reserved.
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