期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 44, 期 3, 页码 431-434出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2011.12.002
关键词
Epithelial Na+ channel; Chytridiomycosis; Batrachochytrium dendrobatidis; Frog skin; Hyponatremia; Hypokalemia
资金
- Australian Research Council [DP1096313]
- National Health and Medical Research Council of Australia [1007447, 1011356]
- NIH/NCRR [P20RR16448]
- NSF [EF-0723871]
One unique physiological characteristic of frogs is that their main route for intake of water is across the skin. In these animals, the skin acts in concert with the kidney and urinary bladder to maintain electrolyte homeostasis. Water absorption across the skin is driven by the osmotic gradient that develops as a consequence of solute transport. Our recent study demonstrated that chytridiomycosis, an infection of amphibian skin by the fungal pathogen, Batrachochytrium dendrobatidis, inhibits epithelial Na+ channels, attenuating Na+ absorption through the skin. In frogs that become severely affected by this fungus, systemic depletion of Na+, K+ and Cl- is thought to cause deterioration of cardiac electrical function, leading to cardiac arrest. Here we review the ion transport mechanisms of frog skin, and discuss the effect of chytridiomycosis on these mechanisms. (C) 2011 Elsevier Ltd. All rights reserved.
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