期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 43, 期 11, 页码 1533-1536出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2011.08.002
关键词
Migraine; TRESK; Calcineurin; Therapeutic; Genetics
Migraine is a severe episodic headache disorder affecting one in five people. Genetic studies have identified mutations in the CACNA1,ATP1A2 and SCN1A genes in the rare familial hemiplegic migraine. Recently, a mutation in the KCNK18 gene, encoding the TRESK two-pore domain potassium channel, was described in a large family with migraine with aura. This review will elaborate on the possible role of the TRESK channel in regulating neuronal excitability, its role in migraine pathogenesis, and on promising therapeutic opportunities targeting this channel. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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