期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 42, 期 3, 页码 421-424出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2009.08.018
关键词
Sox2; Neural stem cells; Gene regulation; Neural development; Animal models
资金
- Italian Ministery for University and Research
- Telethon
- Cariplo foundation
- Fondazione Banca del Monte di Lombardia
- Associazione Italiana Ricerca sul Cancro (AIRC
- NIH [EY018261, MH071822]
Throughout vertebrate evolution, Sox2 marks the developing nervous system from its earliest developmental stages and, therein, the most undifferentiated precursor cells, including stem cells. Recent gene targeting studies investigated the function of Sox2 in two neuronal systems: the developing eye and brain. These studies uncovered a requirement for Sox2 in the maintenance of neural stem cells, as well as a downstream role in the differentiation of specific neuron sub-types. In both systems, Sox2 action is markedly dose-dependent, and downstream-target gene studies are beginning to reveal the mechanisms of Sox2 function. (C) 2009 Published by Elsevier Ltd.
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