期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 41, 期 4, 页码 711-716出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2008.09.020
关键词
Cerebral malaria; Heme oxygenase-1; Carbon monoxide; Methemoglobin; Free heme
资金
- Fundacao para a Ciencia e Tecnologia, Portugal [BPD/26633/2006, BPD/31598/2006, PTDC/SAU-MII/64125/2006]
- EMBO Young Investigator Program
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-MII/64125/2006] Funding Source: FCT
Malaria causes more than 1 million deaths every year with cerebral malaria (CM) being a major cause of death in Sub-Saharan African children. The nature of the malaria-associated pathogenesis is complex and multi-factorial. A unified hypothesis involving sequestration of infected red blood cells, systemic host inflammatory response and hemostasis dysfunction has been proposed to explain the genesis of CM. In this review, we discuss the role of hemolysis, methemoglobin and free heme in CM, brought to light by our recent studies in mice as well as by other studies in humans. (C) 2008 Elsevier Ltd. All rights reserved.
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