Reassessing the amyloid cascade hypothesis of Alzheimer's disease

Since its inception, the amyloid cascade hypothesis has dominated the field of Alzheimer's disease (AD) research and has provided the intellectual framework for therapeutic intervention. Although the details of the hypothesis continue to evolve, its core principle has remained essentially unaltered. it posits that the annyloid-beta peptides, derived from amyloid precursor protein (APP), are the root cause of AD. Substantial genetic and biochemical data support this view, and yet a number of findings also run contrary to its tenets. The presence of familial AD mutations in APP and presenilins, demonstration of A beta toxicity, and studies in mouse models of AD all support the hypothesis, whereas the presence of A beta plaques in normal individuals, the uncertain nature of the pathogenic A beta species, and repeated disappointments with A beta-centered therapeutic trials are inconsistent with the hypothesis. The current state of knowledge does not prove nor disprove the amyloid hypothesis, but rather points to the need for its reassessment. A view that A beta is one of the factors, as opposed to the factor, that causes AD is more consistent with the present knowledge, and is more likely to promote comprehensive and effective therapeutic strategies. (C) 2009 Elsevier Ltd. All rights reserved.