Potential role of electrochemotherapy for the treatment of soft tissue sarcoma: First insights from preclinical studies in animals

Local management of soft tissue sarcoma in humans generally involves multi-modality approaches whose cornerstones are surgery combined with radiation therapy. The usual radiation protocols are based on preoperative, intraoperative, or postoperative external beam treatment or adjuvant brachytherapy. The aim of these strategies is to maximize tumor control while minimizing side effects, especially in the case of limb sarcomas. Unfortunately, the rate of local wound complication associated with aggressive surgical management and radiation therapy are still elevated. Electrochemotherapy is an anticancer technique that gained popularity over the past 15 years. It involves the administration of anticancer agents to the application of permeabilizing pulses so to increase the uptake of antitumor molecules. Goal of this review is to underline the advances in this field obtained from animal studies in order to point out the possible therapeutic applications of this technique for the treatment of soft tissue sarcomas in humans. (c) 2007 Elsevier Ltd. All rights reserved.