期刊
INTERNATIONAL JOURNAL OF AUDIOLOGY
卷 51, 期 5, 页码 413-417出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14992027.2011.652677
关键词
Tinnitus; auditory cortex; emotion; hearing; functional connectivity; resting-state fMRI
资金
- Ministry of Health Welfare, Korea [A092106]
- Korea Health Promotion Institute [A092106] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Objective: We report a case study on possible alterations in resting-state functional connectivity between the auditory network and non-auditory brain regions in tinnitus patients. Design: Independent component analyses were performed to evaluate coherent spontaneous activity in distributed brain networks. The resting-state functional connectivity scores between the right and left auditory networks were measured. Direct comparison of resting-state connectivity between tinnitus patients and controls was made using a two-sample t-test. Study sample: Four patients (three male, one female; mean age 45 +/- 3.92 years) with chronic tinnitus lateralized to the left ear, and six age-matched controls (four male, two female; mean age 45 +/- 2.76 years) participated in this case study. Results: The average resting-state functional connectivity (FC) score between the left and right auditory cortical regions was significantly lower in tinnitus patients than in controls (P < 0.05). Direct comparison between patients and controls showed that increased functional connectivity caused by tinnitus occurred predominantly in the left amygdala and in the dorsomedial prefrontal cortex. Conclusions: Our pilot study suggested that resting state functional magnetic resonance imaging (fMRI) could be useful to investigate possible alterations in resting-state neuronal activity between the auditory and non-auditory networks in tinnitus patients.
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