期刊
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
卷 37, 期 3, 页码 241-252出版社
WICHTIG EDITORE
DOI: 10.5301/ijao.5000306
关键词
Total artificial heart; Left chamber; Fluid-structure interaction simulation; PIV validation; Heart valve orientation; Numerical washout study
资金
- European Union (EU)
- German Federal State of North Rhine-Westphalia [005-GW01-206B]
- Erich and Hanna Klessmann Foundation
Purpose: For blood pumps with long term indication, blood stagnation can result in excessive thromboembolic risks for patients. This study numerically investigates the washout performance of the left pump chamber of a pulsatile total artificial heart (TAH) as well as the sensitivity of the rotational orientation of the inlet bileaflet mechanical heart valve (MHV) on blood stagnation. Methods: To quantitatively evaluate the washout efficiency, a fluid-structure interaction (FSI) simulation of the artificial heart pumping process was combined with a blood washout model. Four geometries with different orientations (0 degrees, 45 degrees, 90 degrees and 135 degrees) of the inlet valve were compared with respect to washout performance. Results: The calculated flow field showed a high level of agreement with particle image velocimetry (PIV) measurements. Almost complete washout was achievable after three ejection phases. Remains of old blood in relation to the chamber volume was below 0.6% for all configurations and were mainly detected opposite to the inlet and outlet port at the square edge where the membrane and the pump chamber are connected. Only a small variation in the washout efficiency and the general flow field was observed. An orientation of 0 showed minor advantages with respect to blood stagnation and recirculation. Conclusions: Bileaflet MHVs were demonstrated to be only slightly sensitive to rotation regarding the washout performance of the TAH. The proposed numerical washout model proved to be an adequate tool to quantitatively compare different configurations and designs of the artificial organ regarding the potential for blood stagnation where experimental measurements are limited.
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