期刊
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
卷 34, 期 9, 页码 781-788出版社
SAGE PUBLICATIONS LTD
DOI: 10.5301/ijao.5000052
关键词
Implant-related osteomyelitis; Staphylococcus aureus; FnBPA; SpA; Osteoblasts; Internalization
Implant-related osteomyelitis is a severe and deep infection of bone that arises and develops all around an implant. Staphylococcus aureus is the first cause of osteomyelitis, whether implant-related or not. Bone is an optimal substratum for S. aureus, since this bacterium expresses various adhesins by which can adhere to bone proteins and to the biomaterial surfaces coated with the proteins of the host extracellular matrix. S. aureus is able not only to colonize bone tissues, but also to invade and disrupt them by entering bone cells and inducing cell death and osteolysis. Here we illustrate the pathogenetic mechanisms that can explain how the osteomyelitis sets in and develops around an implant.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据