期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 39, 期 5, 页码 435-439出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2012.01.007
关键词
Mycobacterium tuberculosis; Fluoroquinolone resistance; gyrA; gyrB; Mutations
资金
- J-GRID (Japan Initiative for Global Research Network on Infectious Diseases) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan (MEXT)
- Global Center of Excellence (GCOE) from MEXT
- US-Japan Cooperative Medical Science Program
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [21500806, 24590651] Funding Source: KAKEN
Minimum inhibitory concentrations of sitafloxacin, gatifloxacin, moxifloxacin, sparfloxacin, levofloxacin and ciprofloxacin against 59 ciprofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Japan were determined. The isolates were most susceptible to sitafloxacin and gatifloxacin. To understand better the basis for drug resistance, nucleotide sequences encoding the gyrA and gyrB quinolone resistance-determining region were determined. Predicted amino acid sequences revealed distinct mutational patterns likely to be responsible for fluoroquinolone resistance. Double gyrA mutations as well as mutations in both gyrA and gyrB correlated with increased resistance to all fluoroquinolones. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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