期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 40, 期 3, 页码 264-267出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2012.05.017
关键词
Integrons; Gene cassettes; Multidrug-resistant
资金
- National Natural Science Foundation of China [30470099]
Non-duplicate multidrug-resistant Gram-negative bacteria (n = 1447) isolated from January 2008 to December 2009 were investigated for the presence of integrons as well as characterisation of gene cassettes. Among 825 strains carrying the class 1 integrase gene intI1, 461 gene cassette-positive isolates were found. Thirty-eight distinct gene cassette arrays were identified by restriction fragment length polymorphism (RFLP) and DNA sequencing analyses. In addition, several novel gene cassette arrays detected in this study were reported for the first time in some species: one in Escherichia coli, six in Klebsiella pneumoniae, six in Enterobacter cloacae, three in Enterobacter aerogenes, one in Proteus mirabilis, one in Acinetobacter spp., one in Stenotrophomonas maltophilia and one in Pseudomonas putida. Among them, three cassettes, including HAD-like, Delta MFS-1 and qnrVC-like genes, were originally detected in integrons. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.
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