期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 36, 期 1, 页码 33-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2010.02.020
关键词
Candida albicans; Candidiasis; Echinocandins; Anidulafungin; Rapid killing; Drug efficacy; Murine model
资金
- Pfizer Pharmaceuticals
In this study, we investigated the in vivo efficacy of anidulafungin during the early phase of disseminated candidiasis in a neutropenic murine model and compared the results with those obtained for fluconazole. Antifungal efficacy was evaluated by reduction of fungal burden in the tissues of infected animals at periodic intervals during the first day of treatment. The fungal burden in tissues of drug-treated mice was reduced compared with controls in a time-dependent manner. At 24 h after drug treatment, a > 2 log(10) reduction of fungal burden in the kidney was obtained in the anidulafungin- and caspofungin-treated mice compared with a ca. 1.2 log(10) reduction in fluconazole-treated mice (P < 0.003). There was no significant difference in the splenic fungal burden at 24 h. Thus, echinocandins have excellent antifungal activity in the early phase of disseminated Candida albicans infection and may contribute to an improved outcome in critically ill immunocompromised/neutropenic patients. Published by Elsevier B. V. on behalf of International Society of Chemotherapy.
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