期刊
INTERNATIONAL JOURNAL OF ANDROLOGY
卷 35, 期 4, 页码 485-490出版社
WILEY
DOI: 10.1111/j.1365-2605.2011.01222.x
关键词
ART; chromatin; DNA damage; ICSI; infertility
类别
资金
- Viborg County Research Foundation
- Swedish Governmental Founding for Clinical Research
- Swedish Research Council [K2005-72X-14545-03A]
- Swedish Cancer Foundation [CAN 2006/1142]
- Gunnar Nilssons cancer Foundation
- Malmo University Hospital Foundation
High levels of spermatozoa DNA damage hinder fertility in vivo but not in vitro. It is a source of worry that following in vitro fertilization (IVF) spermatozoa DNA damage, if not repaired by the oocyte, might have a negative impact on the offspring. The aim of this study was to assess if a high spermatozoa DNA Fragmentation Index (DFI) is associated with alterations in birthweight (BW) and/or gestational length in IVF children. One hundred and thirty-one singleton pregnancies established by standard IVF or intracytoplasmic sperm injection (ICSI) were included in the study. DFI was measured by sperm chromatin structure assay (SCSA) in semen samples used for fertilization. DFI was categorized as low and high, using 20, 30, 40 and 50% as cut-off levels. Birthweight, gestational age, as well as gestational age adjusted BW score were used in a linear regression model as end points For none of the tested birth characteristics, statistically significant differences between the groups with low and high DFI were seen regardless of whether 20, 30, 40 or 50% were used as cut-off levels, both when the IVF and ICSI data were merged or analysed separately. Spermatozoa DNA damage as assessed by SCSA is not associated with BW or gestational length in IVF and ICSI children.
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