期刊
MEDICINAL RESEARCH REVIEWS
卷 35, 期 5, 页码 1072-1096出版社
WILEY
DOI: 10.1002/med.21357
关键词
noscapine; noscapinoids; microtubule targeting drugs; antineoplastic drugs; centrosome declustering drugs
资金
- NCI NIH HHS [U01 CA179671, R03 CA188527, R01 CA169127] Funding Source: Medline
Given its manifold potential therapeutic applications and amenability to modification, noscapine is a veritable Renaissance drug worthy of commemoration. Perhaps the only facet of noscapine's profile more astounding than its versatility is its virtual lack of side effects and addictive properties, which distinguishes it from other denizens of Papaver somniferum. This review intimately chronicles the rich intellectual and pharmacological history behind the noscapine family of compounds, the length of whose arms was revealed over decades of patient scholarship and experimentation. We discuss the intriguing story of this family of nontoxic alkaloids, from noscapine's purification from opium at the turn of the 19th century in Paris to the recent torrent of rationally designed analogs with tremendous anticancer potential. In between, noscapine's unique pharmacology; impact on cellular signaling pathways, the mitotic spindle, and centrosome clustering; use as an antimalarial drug and cough suppressant; and exceptional potential as a treatment for polycystic ovarian syndrome, strokes, and diverse malignancies are catalogued. Seminal experiments involving some of its more promising analogs, such as amino-noscapine, 9-nitronoscapine, 9-bromonoscapine, and reduced bromonoscapine, are also detailed. Finally, the bright future of these oftentimes even more exceptional derivatives is described, rounding out a portrait of a truly remarkable family of compounds. (C) 2015 Wiley Periodicals, Inc.
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