期刊
MEDICINAL CHEMISTRY RESEARCH
卷 24, 期 6, 页码 2732-2741出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-015-1322-z
关键词
5-Amino-1-phenyl-1,2,4-triazole; MCR; Imidazo[2,1-c][1,2,4]triazole; Antioxidant; Antimicrobial
资金
- Ecole Nationale Superieure de Techniques Avancees (ENSTA)
The Groebke-type multicomponent reaction between 5-amino-1,2,4-triazole derivatives, aromatic aldehydes and isocyanides has been studied from the viewpoint of convenient generation of combinatorial arrays of imidazo[2,1-c][1,2,4]triazoles. The reaction is considered to proceed via the formation of an iminium species followed by a [4 + 1] cyclo addition with the isocyanides using scandium triflate as a Lewis acid catalyst. The synthesized imidazo[2,1-c][1,2,4]triazole derivatives 4a, 4b, 4f and 4g were screened for antibacterial, antifungal and antioxidant activities. Among the tested compounds, 4b followed by 4f showed potent antibacterial and antifungal activities. All of these compounds were also screened in vitro for the antioxidant activity using DPPH assay. Most of them have shown very significant antioxidant activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据