期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 44, 期 3-4, 页码 251-261出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2013.12.003
关键词
Lungworms; Dictyocaulus spp.; Transcriptome; Host-parasite interactions
类别
资金
- Australian Research Council (ARC)
- Australian National Health & Medical Research Council (NHMRC)
- Victorian Life Sciences Computation Initiative (VLSCI) [VR0007]
- Alexander von Humboldt Foundation, Germany
- Melbourne Water Corporation, Australia
- Howard Hughes Medical Institute (HHMI), USA
- National Institutes of Health (NIH)
Parasitic nematodes cause diseases of major economic importance in animals. Key representatives are species of Dictyocaulus (=lungworms), which cause bronchitis (=dictyocaulosis, commonly known as husk) and have a major adverse impact on the health of livestock. In spite of their economic importance, very little is known about the immunomolecular biology of these parasites. Here, we conducted a comprehensive investigation of the adult transcriptome of Dictyocaulus filaria of small ruminants and compared it with that of Dictyocaulus viviparus of bovids. We then identified a subset of highly transcribed molecules inferred to be linked to host-parasite interactions, including cathepsin B peptidases, fatty-acid and/or retinol-binding proteins, beta-galactoside-binding galectins, secreted protein 6 precursors, macrophage migration inhibitory factors, glutathione peroxidases, a transthyretin-like protein and a type 2-like cystatin. We then studied homologues of D. filaria type 2-like cystatin encoded in D. viviparus and 24 other nematodes representing seven distinct taxonomic orders, with a particular focus on their proposed role in immunomodulation and/or metabolism. Taken together, the present study provides new insights into nematode-host interactions. The findings lay the foundation for future experimental studies and could have implications for designing new interventions against lungworms and other parasitic nematodes. The future characterisation of the genomes of Dictyocaulus spp. should underpin these endeavours. (C) 2014 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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