期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 44, 期 9, 页码 669-674出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2014.05.001
关键词
Asthma; ES-62; Parasitic helminth; Immunomodulation; Phosphorylcholine
类别
资金
- Biotechnology and Biological Sciences Research Council (UK)
- Wellcome Trust (UK)
- American Asthma Foundation (USA)
- Biotechnology and Biological Sciences Research Council [BB/E013929/1] Funding Source: researchfish
- BBSRC [BB/E013929/1] Funding Source: UKRI
ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs I la and 12b thus represent starting points for novel drug development for allergies such as asthma. (C) 2014 The Authors. Published by Elsevier Ltd. on behalf of Australian Society for Parasitology Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
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