期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 44, 期 11, 页码 827-836出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2014.06.005
关键词
Parasitic nematode; RIO kinase; Structure; Function
类别
资金
- National Health and Medical Research Council (NHMRC) of Australia
- Australian Research Council (ARC)
- Victorian Life Sciences Computation Initiative (VLSCI), Australia on its Peak Computing Facility at the University of Melbourne, Australia, an initiative of the Victorian Government [VR0007]
- Howard Hughes Medical Institute (HHMI), USA
- National Institutes of Health (NIH), USA
Despite right open reading frame kinases (RIOKs) being essential for life, their functions, substrates and cellular pathways remain enigmatic. In the present study, gene structures were characterised for 26 RIOKs from draft genomes of parasitic and free-living nematodes. RNA-seq transcription profiles of riok genes were investigated for selected parasitic nematodes and showed that these kinases are transcribed in developmental stages that infect their mammalian host. Three-dimensional structural models of Caenorhabditis elegans RIOKs were predicted, and elucidated functional domains and conserved regions in nematode homologs. These findings provide prospects for functional studies of riok genes in C elegans, and an opportunity for the design and validation of nematode-specific inhibitors of these enzymes in socioeconomic parasitic worms. (C) 2014 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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