期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 44, 期 12, 页码 893-899出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2014.07.008
关键词
Malaria; Plasmodium falciparum; Artemisinin; Pulse drug assay; Synchronisation
类别
资金
- Australian Research Council
- Australian National Health & Medical Research Council
Recent reports demonstrate that failure of artemisinin-based antimalarial therapies is associated with an altered response of early blood stage Plasmodium falciparum. This has led to increased interest in the use of pulse assays that mimic clinical drug exposure for analysing artemisinin sensitivity of highly synchronised ring stage parasites. We report a methodology for the reliable execution of drug pulse assays and detail a synchronisation strategy that produces well-defined tightly synchronised ring stage cultures in a convenient time-frame. Crown Copyright (C) 2014 Published by Elsevier Ltd. on behalf of Australian Society for Parasitology Inc. All rights reserved.
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