期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 43, 期 1, 页码 1-10出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2012.11.002
关键词
Malaria; Plasmodium falciparum; Merozoite; Invasion; Inhibitors; Vaccines
类别
资金
- Australian Research Council
- National Health and Medical Research Council of Australia
- Australian Government
- University of Melbourne, Australia, Faculty of Medicine, Dentistry and Health Sciences
- Victorian State Government Operational Infrastructure Support, Australia
Merozoite invasion of human red blood cells by Plasmodium falciparum is essential for blood stage asexual replication and the development of malaria disease. Despite this, many of the processes involved in invasion are poorly understood. Recent advances have been made in methods to isolate viable merozoites for studies of invasion. The application of these approaches is providing new insights into the kinetics of invasion and merozoite survival, as well as proteins and interactions involved in invasion, and will facilitate the development and testing of anti-merozoite vaccines and the identification of invasion-inhibitory compounds with potential for drug development. This review discusses these recent advances and considers potential avenues for future research. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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