期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 42, 期 6, 页码 529-534出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2012.03.004
关键词
Malaria; Plasmodium; Experimental crosses; Quantitative trait loci; Genetic mapping; Recombination
类别
资金
- Wellcome Trust, UK [078749, 091791]
- European Union (MALSIG)
- European Union (TM-REST)
- European Union (EviMalaR)
We review the principles of linkage analysis of experimental genetic crosses and their application to Plasmodium falciparum. Three experimental genetic crosses have been performed using the human malaria parasite P. falciparum. Linkage analysis of the progeny of these crosses has been used to identify parasite genes important in phenotypes such as drug resistance, parasite growth and virulence, and transmission to mosquitoes. The construction and analysis of genetic maps has been used to characterise recombination rates across the parasite genome and to identify hotspots of recombination. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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