期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 42, 期 9, 页码 801-807出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2012.06.002
关键词
Schistosoma japonicum; Insulin receptor; Ligand domain; Transmission blocking veterinary vaccine
类别
资金
- National Health and Medical Research Council, Australia
Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S. japonicum insulin receptor 2 (SjLD2) in three independent murine vaccine/challenge trials. Compared with controls, vaccination of mice with SjLD2 resulted in a significant reduction in faecal eggs, the stunting of adult worms and a reduction in liver granuloma density in all three trials. Furthermore, in the final trial, in which mature intestinal eggs were also quantified, there was a reduction in their number. These results suggest that development of a vaccine based on rSjLD2 for preventing transmission of zoonotic schistosomiasis is feasible. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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