期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 41, 期 2, 页码 155-163出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2010.08.003
关键词
Cerebral malaria; Anti-malarial drug; Mouse model; CD8(+) T cells; Plasmodium berghei
类别
资金
- National Health and Medical Research Council of Australia
- Australian Research Council
- Sir Zelman Cowen Universities' Fund, Australia
- Israeli Science Foundation, Israel
- Rebecca L Cooper Foundation, Australia
Cerebral malaria (CM) is a fatal complication of Plasmodium falciparum infection. Using a well defined murine model, we observed the effect on disease outcome of temporarily reducing parasite burden by anti-malarial drug treatment. The anti-malarial treatment regime chosen decreased parasitaemia but did not cure the mice, allowing recrudescence of parasites. These mice were protected against CM, despite their parasitaemia having increased, following treatment cessation, to levels surpassing that associated with CM in mice not treated with the drug. The protection was associated with reduced levels of cytokines, chemokines, CD8(+) T cells and parasites in the brain. The results suggest that the development of the immunopathological response that causes CM depends on a continuous stimulus provided by parasitised red blood cells, either circulating or sequestered in small vessels. (C) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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