期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 41, 期 12, 页码 1249-1252出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2011.07.007
关键词
Schistosoma; Polymorphism; Tetraspanin-2; Genotype; Kozak sequence; Vaccine
类别
资金
- NIAID [HHSN272201000009I]
- National Institutes of Health, USA, National Center for Research Resources [1P20RR18754]
- NIAID, USA [1R56AI087807-01]
A vaccine against schistosomiasis would contribute significantly to reducing the 3-70 million disability-adjusted life years lost annually to the disease. Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S. mansoni-infected mice. The EC-2 loop of Schistosoma japonicum TSP-2, however, has been found to be highly polymorphic, perhaps diminishing the likelihood that this antigen can be used for vaccination against this species. Here, we examine polymorphism of the EC-2 of Sm-TSP-2 in genetically unique worms derived from six individuals from Kisumu, Kenya. (C) 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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