期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 40, 期 5, 页码 515-519出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2010.01.006
关键词
Taenia solium; Vaccination; Pigs; TSOL18; Field trial; Cameroon
类别
资金
- Wellcome Trust
- Animal Health in the Developing World [075818]
- Australian National Health and Medical Research Council [350279, 400109, 628320]
A pilot field trial of the TSOL18 vaccine was undertaken in Cameroon. Two hundred and forty, 2-3 month-old piglets were distributed to 114 individual households in pairs. Vaccinated animals received three immunisations with 200 mu g TSOL18 plus 5 mg Quil A and 30 mg/kg oxfendazole at the time of the second immunisation. Necropsies were undertaken when the pigs were approximately 12 months of age. Viable Taenia solium cysticerci were identified in 20 control pigs (prevalence 19.6%); no cysticerci were found in any of the vaccinated animals (P < 0.0001). Combined application of TSOL18 vaccination and a single oxfendazole treatment in pigs may be a relatively simple and sustainable procedure that has the potential to control T. solium transmission in endemic areas and, indirectly, reduce the number of new cases of neurocysticercosis in humans. (C) 2010 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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