期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 38, 期 12, 页码 1377-1382出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijpara.2008.06.001
关键词
Blastocystis hominis; MLOs; Circular DNA molecule; Iron-hydrogenase
类别
资金
- Ministere de I'Education Nationale de l'Enseignement Superieur et de Recherche (MENESR)
Blastocystis hominis is an anaerobic parasite of the human intestinal tract belonging to the Stramenopile group. Using genome sequencing project data, we describe here the complete sequence of a 29,270-bp circular DNA molecule that presents mitochondrial features (such as oxidative phosphorylation complex I subunits) but lacks complexes III, IV and V. Transmission electron microscopy analyses reveal that this molecule, as well as mitochondrial (NADH:ubiquinone oxidoreductase subunit 7 (NAD7), beta-succinyl-CoA synthetase (beta-SCS)) and hydrogenosomal (pyruvate ferredoxin oxido-reductase (PFOR), iron-hydrogenase) proteins, are located within double-membrane surrounded-compartments known as mitochondria-like organelles (MLOs). As there is no evidence for hydrogen production by this organism, we suggest that MLOs are more likely anaerobic mitochondria. (C) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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