Topology optimization of microfluidic mixers

This paper demonstrates the application of the topology optimization method as a general and systematic approach for microfluidic mixer design. The mixing process is modeled as convection dominated transport in low Reynolds number incompressible flow. The mixer performance is maximized by altering the layout of flow/non-flow regions subject to a constraint on the pressure drop between inlet and outlet. For a square cross-sectioned pipe the mixing is increased by 70% compared with a straight pipe at the cost of a 2.5 fold increase in pressure drop. Another example where only the bottom profile of the channel is a design domain results in intricate herring bone patterns that confirm findings from the literature. Copyright (C) 2008 John Wiley & Sons, Ltd.