期刊
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
卷 28, 期 4, 页码 456-471出版社
WILEY
DOI: 10.1002/cnm.1477
关键词
abdominal aortic aneurysm; finite element analysis; FDG-PET; CT; inflammation; mechanotransduction; metabolic activity
类别
资金
- German Science Foundation/Deutsche Forschungsgemeinschaft (DFG) within AOBJ [GE2254/1-1, RE3146/1-1, 584483]
- International Graduate School of Science and Engineering (IGSSE) of the Technische Universitat Munchen, Germany [3-07]
Mechanobiological interactions are essential for the adaption of the cardiovascular system to altered environmental and internal conditions, but are poorly understood with regard to abdominal aortic aneurysm (AAA) pathogenesis, growth and rupture. In the present study, we therefore calculated mechanical AAA quantities using nonlinear finite element methods and correlated these to [18F]-fluorodeoxyglucose (FDG)-metabolic activity in the AAA wall detected by positron emission tomography/computed tomography (PET/CT). The interplay between mechanics and FDG-metabolic activity was analyzed in terms of maximum values and the three-dimensional spatial relationship, respectively.
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