4.7 Article

Inflammatory cytokines in Paget's disease of bone

期刊

INTERNATIONAL IMMUNOPHARMACOLOGY
卷 18, 期 2, 页码 277-281

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2013.12.003

关键词

Paget's disease of bone; Cytokines; TNF alpha; Interleukin 1 beta; Interleukin 6; Interleukin 17

资金

  1. Conselho Nacional de Pesquisa (CNPq)

向作者/读者索取更多资源

This study was undertaken to evaluate the expression of inflammatory cytokines in patients with Paget's disease of bone (PDB). Serum levels of tumoral necrosis factor-alpha, interleukin 1 beta, interleukin-6 and interleukin-17 were measured in 51 patients with PDB and in 24 controls with primary osteoarthritis. Compared to controls, patients with Paget's disease of bone presented higher levels of interleukin 6 and reduced interleukin 17, but levels of tumoral necrosis factor alpha and interleukin 1 beta did not differ significantly. We found no significant differences when patients were compared according to disease activity or current treatment. There were no correlations between cytokine levels and bone-specific alkaline phosphatase or extension of Paget's disease of bone on bone scintigraphs. In conclusion, patients with PDB present significant differences on levels of certain cytokines in comparison to primary osteoarthritis patients, but these alterations did not appear to have a clear correlation with parameters of disease activity or severity. (C) 2013 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据