期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 16, 期 2, 页码 199-209出版社
ELSEVIER
DOI: 10.1016/j.intimp.2013.03.017
关键词
Colorectal cancer; Toll-like receptors; Susceptibility; Tumorigenesis; Treatment; Prognosis
资金
- Tehran University of Medical Sciences [90-04-30-16337]
Intestinal homeostasis is dependent on the proper host/microbiota interaction via pattern recognition receptors. Toll-like receptors are a specialised group of membrane receptors which detect pathogen-associated conserved structures. They are present in the intestinal tract and are required for intestinal homeostasis. Dysregulation in the Toll-like receptor signalling can conceivably result in a dysregulated immune response which could contribute to major intestinal pathologies including colorectal cancer. Evidence for the role of microbiota and toll-like receptors in colorectal cancer is emerging. In this report the evidence for the contribution of toll-like receptors to the pathogenesis of colorectal cancer; potential mechanisms affecting toll-like receptor signalling; and their therapeutic targeting in colorectal cancer are reviewed. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据