4.7 Article

Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation

期刊

INTERNATIONAL IMMUNOPHARMACOLOGY
卷 17, 期 3, 页码 617-624

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2013.08.002

关键词

Ovatodiolide; Dendritic cell maturation; CD80; CD86; MHC class II; Inflammatory cytokines

资金

  1. National Science Council of Taiwan [NSC 100-2113-M-324-001-MY3, 101-2811-M-324-001, 101-2313-B-039-004-MY3]

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Ovatodiolide was a unique macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica. The present study attempted to examine the ovatodiolide effects on dendritic cell (DC) maturation and immuno-stimulatory activities. The effects of ovatodiolide on DC surface molecule expression, cytokine production, and capacity to induce T-cell differentiation were examined in ovalbumin (OVA)/thymic stromal lymphopoietin (TSLP)-stimulated DCs. Ovatodiolide attenuated the expression of DC surface molecules CD80, CD86, histocompatibility complex (MHC) class II, and Th2 subset of CD4(+) T cells co-stimulatory molecule-OX40 ligand production. Additionally, ovatodiolide suppressed the CD4(+) T cells proliferation, and production of inflammatory cytokines interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha. This study may be useful to develop ovatodiolide as a therapeutic adjuvant. (C) 2013 Elsevier B.V. All rights reserved.

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