期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 12, 期 1, 页码 139-143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2011.11.003
关键词
Liquiritigenin; MC3T3-E1 cells; Differentiation; Bone resorbing cytokine
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [20110005020]
Liquiritigenin is one of the flavonoids present in Glycyrrhizae radix. In the present study, the effects of liquiritigenin on the function of osteoblastic MCT3-E1 cells were studied. Liquiritigenin caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis, mineralization, and glutathione content in the cells (P<0.05). Moreover, liquiritigenin significantly decreased the production of reactive oxygen species (ROS) and osteoclast differentiation inducing factors such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and receptor activator of nuclear factor-kappa B ligand (RANKL) in the presence of antimycin A, which inhibits mitochondrial electron transport and has been used as a ROS generator. These results demonstrate that liquiritigenin may have positive effects on skeletal structure. (C) 2011 Elsevier B.V. All rights reserved.
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