期刊
INTERNATIONAL IMMUNOLOGY
卷 26, 期 9, 页码 495-499出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxu066
关键词
IBD; infection; inflammasome; intestine; microbiota
类别
资金
- Keith Landesman Memorial Fellowship of the Cancer Research Institute
- Cancer Research Institute
- Howard Hughes Medical Institute
Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.
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