期刊
INTERNATIONAL IMMUNOLOGY
卷 26, 期 2, 页码 61-69出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxt060
关键词
antibody; CTLA-4; T-follicular helper cells; T-follicular regulatory cells
类别
资金
- Japan Society for Promotion of Science (JSPS) [25860356]
- Core Research for Evolutional Science and Technology (CREST) from Japan Science and Technology Agency
- [20002007]
- Grants-in-Aid for Scientific Research [25860356] Funding Source: KAKEN
T-reg cells use a wide range of mechanisms to regulate B-cell responses.T-reg cells are essential for the maintenance of immune homeostasis and prevention of autoimmunity. In humoral immune responses, loss of T-reg cell function causes increased levels of serum autoantibodies, hyper-IgE, spontaneous generation of germinal centres, and enhanced numbers of specialised T follicular helper cells (T-fh cells) controlled by the lineage-defining transcription factor BCL-6 (B-cell lymphoma 6). Recent studies have demonstrated that a subset of T-reg cells [T follicular regulatory (T-freg) cells] are able to co-opt the follicular T-cell program by gaining expression of BCL-6 and travelling to the follicle where they have an important role in the control of expansion of T-fh cells and the germinal centre reaction. However, the mechanisms by which they exert this control are still under investigation. In this review, we discuss the effects of T-reg cells on humoral immunity and the mechanisms by which they exert their regulatory function.
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